In this paper, we present the design of a clinical decision support system (CDSS) for monitoring comorbid conditions. Specifically,\nwe address the architecture of a CDSS by characterizing it fromthree layers and discuss the algorithms in each layer.Alsowe address\nthe applications of CDSSs in a few real scenarios and analyze the accuracy of a CDSS in consideration of the potential conflicts when\nusing multiple clinical practice guidelines concurrently. Finally, we compare the system performance in our design with that in the\nother design schemes. Our study shows that our proposed design can achieve a clinical decision in a shorter time than the other\ndesigns, while ensuring a high level of system accuracy.
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